|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico.
|
20013659 |
2009 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the association of polymorphisms in genes encoding three key proteins of DNA base excision repair (BER): the OGG1 Ser326Cys, the MUTYH Tyr165Cys and the XRCC1 Arg399Gln with the risk of childhood acute lymphoblastic leukemia (ALL).
|
20364408 |
2011 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped polymorphisms of X-ray repair cross-complimenting group 1 (XRCC1) codon 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln), and xeroderma pigmentosum group D (XPD) codon 312 (Asp to Asn) and 715 (Lys to Gln) in 108 children with ALL and 317 healthy controls using PCR-RFLP method.
|
16435384 |
2007 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In stratified analyses by tumor type, Arg399Gln was associated with higher acute lymphoblastic leukemia (ALL) risk (AA vs. GG, OR = 1.50, 95% CI: 1.11-2.02; AA+GA vs. GG, OR = 1.35, 95% CI: 1.02-1.78).
|
24363792 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accordingly, the co-presence of Tyr113His variant of EPHX1 and Arg399Gln variant of XRCC1 in the same individuals significantly increased the risk of childhood ALL up to 2.1-fold (OR = 2.1, P = 0.03).
|
21983886 |
2012 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Basal, H2O2-induced, and postrepair DNA damage; urinary 8-hydroxydeoxyguanosine level as a marker of oxidatively damaged DNA; and serum total antioxidant capacity were measured; XPD Lys751Gln, XRCC1 Arg399Gln, and XRCC1 Arg194Trp polymorphisms were analyzed in childhood acute lymphoblastic leukemia (ALL) survivors.
|
24577548 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia.
|
20394984 |
2010 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
XRCC1 Arg399Gln and Arg194Trp polymorphisms in childhood acute lymphoblastic leukemia risk: a meta-analysis.
|
22712837 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis results suggested that XRCC1 Arg399Gln polymorphism might be associated with elevated childhood ALL risk among Asian population.
|
22529951 |
2012 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), to analyze XPD Asp312Asn, XPD Lys751Gln, XRCC1 Arg194Trp, and XRCC1 Arg399Gln polymorphisms in 70 patients with childhood ALL and in 75 disease-free controls, who were of a similar age.
|
19101034 |
2009 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, the combined XRCC1 Arg194Trp/Trp194Trp variant genotypes were associated with increased risk for ALL in females (OR=5.47; 95% CI=1.49-20.10; p=0.008).
|
19101034 |
2009 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Basal, H2O2-induced, and postrepair DNA damage; urinary 8-hydroxydeoxyguanosine level as a marker of oxidatively damaged DNA; and serum total antioxidant capacity were measured; XPD Lys751Gln, XRCC1 Arg399Gln, and XRCC1 Arg194Trp polymorphisms were analyzed in childhood acute lymphoblastic leukemia (ALL) survivors.
|
24577548 |
2015 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We genotyped polymorphisms of X-ray repair cross-complimenting group 1 (XRCC1) codon 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln), and xeroderma pigmentosum group D (XPD) codon 312 (Asp to Asn) and 715 (Lys to Gln) in 108 children with ALL and 317 healthy controls using PCR-RFLP method.
|
16435384 |
2007 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico.
|
20013659 |
2009 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In this study, we investigated the possible association of X-ray repair cross-complimenting group 1 (XRCC1) Arg399Gln and Arg194Trp variants with the risk of incidence of childhood acute lymphoblastic leukemia (ALL) in Turkish population comprised of 190 healthy controls and 167 ALL patients.
|
20394984 |
2010 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
XRCC1 Arg399Gln and Arg194Trp polymorphisms in childhood acute lymphoblastic leukemia risk: a meta-analysis.
|
22712837 |
2013 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped polymorphisms of X-ray repair cross-complimenting group 1 (XRCC1) codon 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln), and xeroderma pigmentosum group D (XPD) codon 312 (Asp to Asn) and 715 (Lys to Gln) in 108 children with ALL and 317 healthy controls using PCR-RFLP method.
|
16435384 |
2007 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico.
|
20013659 |
2009 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A meta-analysis was performed to examine the association between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and childhood ALL risk.
|
22529951 |
2012 |
|
rs1121404
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined analysis identified a new locus (rs1121404 in WWOX) at 16q23.1 associated with childhood ALL susceptibility (odds ratio (OR) = 1.38, P = 5.29 × 10<sup>-10</sup>), especially in the subtype of B-ALL (OR = 1.39, P = 2.47 × 10<sup>-9</sup>).
|
27094129 |
2016 |
|
rs16754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings identify WT1 SNP rs16754 as a favorable risk marker in pediatric ALL which is independent from known risk factors.
|
26224397 |
2015 |
|
rs1222213359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the association among functional polymorphisms in these two angiogenesis related genes: VEGF (-2578C>A, -1154G>A, and -634G>C) and NOS3 (-786T>C, intron 4 b>a, and Glu298Asp) with prognosis of childhood acute lymphoblastic leukemia (ALL).
|
20510681 |
2010 |
|
rs1310678797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sixteen single nucleotide polymorphisms (SNPs) (CYP3A4*1B A>G, CYP3A5*3 G>A, GSTP1 313 A>G, GSTM1 deletion, GSTT1 deletion, MDR1 exon 21 G>T/A, MDR1 exon 26 C>T, MTHFR 677 C>T, MTHFR 1298 A>C, NR3C1 1088 A>G, RFC 80 G>A, TPMT 238 G>C, TPMT 460 G>A, TPMT 719 A>G, VDR intron 8 G>A, VDR FokI T>C) that have been implicated in the pharmacogenetics of ALL therapy were analyzed by TotalPlex amplification and SNP genotyping.
|
18385010 |
2008 |
|
rs17863783
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Currently, pharmacogenomic testing of all childhood cancer patients with an indication for doxorubicin or daunorubicin therapy for RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 variants is recommended.
|
29713898 |
2018 |
|
rs2853542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the presence of a 28-base pair tandem repeat (rs34743033; 2R3R), a single nucleotide polymorphism present within the 28-base pair repeat on the 3R allele (rs2853542; 3RG>C) and a 6-base pair deletion (rs15126436; TTAAAG) within the TYMS gene in germline DNA of 117 pediatric patients with ALL.
|
30222710 |
2018 |